[HTML][HTML] The biology of TREM receptors
M Colonna - Nature Reviews Immunology, 2023 - nature.com
Nature Reviews Immunology, 2023•nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages.
These receptors have been implicated in inflammation, neurodegenerative diseases, bone
remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure,
ligands, signalling modes and functions of TREMs in humans and mice and discuss the
challenges that remain in understanding TREM biology.
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages.
These receptors have been implicated in inflammation, neurodegenerative diseases, bone
remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure,
ligands, signalling modes and functions of TREMs in humans and mice and discuss the
challenges that remain in understanding TREM biology.
Abstract
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
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