[HTML][HTML] GSK3β inhibition prevents macrophage reprogramming by high-dose methotrexate
I Ríos, B López-Navarro, M Torres-Torresano… - Journal of innate …, 2023 - karger.com
Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute
lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage
reprogramming is being increasingly assessed as an antitumor therapeutic strategy.
However, and although MTX limits the pathogenic action of macrophages in chronic
inflammatory diseases, its effects on tumor-promoting macrophages have not been
previously explored. We now report that MTX shapes the transcriptional and functional …
lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage
reprogramming is being increasingly assessed as an antitumor therapeutic strategy.
However, and although MTX limits the pathogenic action of macrophages in chronic
inflammatory diseases, its effects on tumor-promoting macrophages have not been
previously explored. We now report that MTX shapes the transcriptional and functional …
GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate
BS Palaciosa, MSFÁ Domínguez-Sotoc, IBMGJ Ángel… - 2022 - karger.com
Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute
lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage
reprogramming is being increasingly assessed as an antitumor therapeutic strategy.
However, and although MTX limits the pathogenic action of macrophages in chronic
inflammatory diseases, its effects on tumor-promoting macrophages have not been
previously explored. We now report that MTX shapes the transcriptional and functional …
lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage
reprogramming is being increasingly assessed as an antitumor therapeutic strategy.
However, and although MTX limits the pathogenic action of macrophages in chronic
inflammatory diseases, its effects on tumor-promoting macrophages have not been
previously explored. We now report that MTX shapes the transcriptional and functional …
