Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4′‐trihydroxystilbene) is a plant‐derived polyphenol that was shown to exert diverse anti‐aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini‐review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti‐oxidative and anti‐inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly.